How ZILBRYSQ works

Targeted treatment for gMG, right in your hands

 

ZILBRYSQ targets a key cause of gMG symptoms

gMG symptoms are caused by your immune system's response to harmful antibodies​

In gMG, harmful antibodies bind to receptors at the neuromuscular junction, activating part of your immune system called "complement."

Activated complement proteins, including C5, work together to attack your muscle cells. The resulting damage interrupts signals between nerves and muscles, causing the weakness you may experience.

Anti-AChR antibody activates complement proteins that damage the muscle and interrupt signals

Anti-AChR antibody activates complement proteins that damage the muscle and interrupts signals.
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Disruption of signaling

Disruption of signaling.
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ZILBRYSQ blocks C5, a specific complement protein involved in muscle cell damage

This muscle cell damage can interrupt the signals between nerves and muscles, which is a known cause of gMG symptoms.

By reducing the cause of the muscle cell damage, ZILBRYSQ can help improve those signals between nerves and muscles.*

*The exact mechanism by which ZILBRYSQ works in gMG is unknown.

ZILBRYSQ blocks C5 to help reduce damage

ZILBRYSQ blocks C5 to help reduce damage.
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Less muscle damage helps to improve signaling

Less muscle damage helps to improve signaling.
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Ask your doctor about ZILBRYSQ.

Our Doctor Discussion Guide can help you get the conversation started.

Discussion Guide
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