HOW ZILBRYSQ WORKS

ZILBRYSQ targets a key cause of gMG symptoms

Watch the video to learn more about how ZILBRYSQ works.

 

In addition to the video above, view the images below to learn more about gMG and how ZILBRYSQ works in the body to target a key cause of gMG symptoms.

gMG symptoms are caused by your immune system's response to harmful antibodies

In gMG, harmful antibodies bind to receptors at the neuromuscular junction, activating part of your immune system called "complement."

Activated complement proteins, including C5, work together to attack your muscle cells. The resulting damage interrupts signals between nerves and muscles, causing the weakness you may experience.

Anti-AChR antibodies activate complement proteins that damage the muscle and interrupt signals

Anti-AChR antibody activates complement proteins that damage the muscle and interrupt signals.
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Disruption of signaling

Disruption of signaling.
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ZILBRYSQ blocks C5, a specific complement protein involved in muscle cell damage for people with anti-AChR antibody-positive gMG

This muscle cell damage can interrupt the signals between nerves and muscles, which is a known cause of gMG symptoms.

By reducing the cause of the muscle cell damage, ZILBRYSQ can help improve those signals between nerves and muscles.*

*The exact mechanism by which ZILBRYSQ works in gMG is unknown.

ZILBRYSQ blocks C5 to help reduce damage

ZILBRYSQ blocks C5 to help reduce damage.
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Less muscle damage helps to improve signaling

Less muscle damage helps to improve signaling.
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